Petter Bjornstad

Personal Information
Title Assistant Professor
Expertise Nephropathy
Institution University of Colorado at Denver and Health Sciences Center
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Data Summary
Grants/SubContracts 1
Progress Reports 1
Publications 12
Protocols 0
Committees 2

Dolphin-T1D Study: Define Renal Oxygenation Levels and Perfusion in Hyperfiltration in Adolescents with Type 1 Diabetes
Diabetic kidney disease (DKD) is the leading cause of renal failure in the United States, and a major risk factor for cardiovascular disease. Current treatments, such as control of hyperglycemia and hypertension, are beneficial, but only partially protective in patients with type 1 diabetes (T1D). Clinical trials in DKD have yielded disappointing results, partly due to limited understanding of what initiates DKD, a potentially misguided focus on albuminuria, and lack of intervention at an early stage of disease when benefit is most likely. Therefore, identifying new therapeutic targets to impede progression of DKD remains a public health priority. Early DKD, including hyperfiltration, is common in youth with T1D. Renal hypoxia, stemming from a mismatch between renal oxygen utilization and consumption, is increasingly proposed to be a unifying pathway in the development of DKD. The kidneys have a high-energy requirement to sustain normal hemodynamic function. However, in T1D, there are emerging animal data that the kidneys are not able to sufficiently compensate for hyperfiltration due to the effects of insulin resistance (IR) and mitochondrial dysfunction on fuel utilization. The pathophysiology underlying the relationship between early DKD and renal oxygenation (O2) in T1D is unclear. Accordingly, dedicated translational studies are needed to unravel the complex metabolic pathophysiology behind the development of DKD. Dr. Bjornstad is a young NIDDK funded investigator who is committed to patient-oriented research focused on early DKD. This DiaComp award would provide Dr. Bjornstad with the support necessary to define renal perfusion and O2 (by MRI) in youth with T1D with (n=15) and without (n=15) hyperfiltration by blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) MRI. This innovative application will capitalize on a Juvenile Diabetes Research Foundation funded study of youth with T1D undergoing gold standard assessment of intrarenal hemodynamic function by iohexol and para-aminohippurate clearance. To achieve these goals, Dr. Bjornstad has assembled a nationally-recognized co-investigator team consisting of Dr. Kristen Nadeau, Professor of Pediatric Endocrinology at University of Colorado, Denver (UCD), in addition a Dr. Pottumarthi Prasad (Radiology, U. of Chicago) and David Z. Cherney (Nephrology, U. of Toronto).

Progress Reports

Annual Reports
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 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2021; Items: 1

Vasopressin associated with renal vascular resistance in adults with longstanding type 1 diabetes with and without diabetic kidney disease.
Piani F, Reinicke T, Lytvyn Y, Melena I, Lovblom LE, Lai V, Tse J, Cham L, Orszag A, Perkins BA, Cherney DZI, Bjornstad P
Journal of diabetes and its complications, 2021 (35), 107807

Year: 2020; Items: 7

The New Biology of Diabetic Kidney Disease-Mechanisms and Therapeutic Implications.
Lytvyn Y, Bjornstad P, van Raalte DH, Heerspink HL, Cherney DZI
Endocrine reviews, 2020 (41)
Asymptomatic hyperuricaemia: a silent activator of the innate immune system.
Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ
Nature reviews. Rheumatology, 2020 (16), 75 - 86
Role of sodium-glucose cotransporter 2 inhibition to mitigate diabetic kidney disease risk in type 1 diabetes.
van Raalte DH, Bjornstad P
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020 (35), i24 - i32
Five-year kidney outcomes of bariatric surgery differ in severely obese adolescents and adults with and without type 2 diabetes.
Bjornstad P, Nehus E, Jenkins T, Mitsnefes M, Moxey-Mims M, Dixon JB, Inge TH
Kidney international, 2020 (97), 995 - 1005
Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes.
Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P
Diabetes, 2020
The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?
Hesp AC, Schaub JA, Prasad PV, Vallon V, Laverman GD, Bjornstad P, van Raalte DH
Kidney international, 2020
Tubular Secretion Markers, Glomerular Filtration Rate, Effective Renal Plasma Flow, and Filtration Fraction in Healthy Adolescents.
Seegmiller JC, Wolfe BJ, Albtoush N, Melena I, Gross SP, Vinovskis C, Ix JH, Bjornstad P
Kidney medicine, 2020 (2), 670 - 672

Year: 2019; Items: 4

Renal Hemodynamic Function and RAAS Activation Over the Natural History of Type 1 Diabetes.
Lytvyn Y, Bjornstad P, Lovshin JA, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019
Elevated plasma cyclic guanosine monophosphate may explain greater efferent arteriolar tone in adults with longstanding type 1 diabetes: A brief report.
Bjornstad P, Lovshin JA, Lytvyn Y, Lovblom LE, Scarr D, Boulet G, Farooqi MA, Orszag A, Bai JW, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI
Journal of diabetes and its complications, 2019 (33), 547 - 549
Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.
Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP
Journal of diabetes and its complications, 2019 (33), 648 - 650
Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes.
Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP
Pediatric diabetes, 2019
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