Elevated copeptin, arterial stiffness, and elevated albumin excretion in
adolescents with type 1 diabetes.
Authors Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA,
Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP
Submitted By Petter Bjornstad on 10/14/2019
Status Published
Journal Pediatric diabetes
Year 2019
Date Published 8/1/2019
Volume : Pages Not Specified : Not Specified
PubMed Reference 31433534
Abstract We sought to evaluate copeptin concentrations in adolescents with and without
type 1 diabetes (T1D) and examine the associations between copeptin and measures
of arterial stiffness and kidney dysfunction., This analysis included 169
adolescents with T1D (12-19?years of age, 59% girls, mean HbA1c 9.0?±?1.5% and
diabetes duration of 8.6?±?2.9?years), in addition to 61 controls without T1D.
Arterial stiffness including carotid-femoral pulse wave velocity (CF-PWV),
carotid-radial PWV (CR-PWV), augmentation index normalized to heart rate of
75?bpm (AIx@HR75), and brachial artery distensibility (BAD). Serum copeptin,
urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration
rate (eGFR) by serum creatinine and cystatin C were also assessed., Compared to
controls, adolescents with T1D had higher median (Q1-Q3) copeptin (7.5
[5.2-11.3] vs 6.4 [4.8-8.3] pmol/L, P = .01), mean?±?SD eGFR (121?±?23 vs
112?±?16?mL/min/1.73m2 , P = .002) and lower BAD (7.1?±?1.3 vs 7.2?±?1.2%, P =
.02). Adolescents with T1D in the in high tertile copeptin group (>9.1 pmol/L)
had higher AIx@HR75 (10.7?±?1.2 vs 5?±?1.2, P = .001), CR-PWV (5.30?±?1.0 vs
5.18?±?1.0 m/s, P = .04), and UACR (12?±?1 vs 8?±?1 mg/g, P = .025) compared to
those in low tertile (<5.8 pmol/L) after adjusting for age, sex, and eGFR.
Copeptin inversely associated with CF-PWV independent of age, sex, eGFR, SBP,
and HbA1c in T1D adolescents., Our data demonstrate that elevated copeptin was
associated with worse arterial stiffness in adolescents with T1D. These findings
suggest that copeptin could improve CVD risk stratification in adolescents with