| Authors |
Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van
Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ,
Bjornstad P
|
| Submitted By |
Petter Bjornstad on 8/11/2020 |
| Status |
Published |
| Journal |
Diabetes |
| Year |
2020 |
| Date Published |
7/1/2020 |
| Volume : Pages |
Not Specified : Not Specified |
| PubMed Reference |
32737116 |
| Abstract |
The objective of this study was to compare the ratio of renal oxygen
availability (RO2) to GFR (RO2:GFR), a measure of relative renal hypoxia, in
adolescents with and without type 1 diabetes (T1D) and relate the ratio to
albuminuria, renal plasma flow (RPF), fat mass, and insulin sensitivity (M/I).
RO2 was estimated by blood oxygenation level dependent (BOLD) MRI, fat mass by
DXA, GFR and RPF by iohexol and p-aminohippurate clearance, albuminuria by urine
albumin-to-creatinine ratio (UACR), and M/I from steady-state glucose infusion
rate/insulin (mg/kg/min) by hyperglycemic clamp in 50 adolescents with T1D
(16.1±3.0 years, HbA1c 8.6±1.2%) and 20 controls of similar BMI (16.1±2.9 years,
HbA1c 5.2±0.2%). The RO2:GFR (ms/ml/min) was calculated as renal oxygen
availability (T2*, ms) divided by GFR (ml/min). Whole-kidney RO2:GFR was 25%
lower in adolescents with T1D vs. controls (p<0.0001). In adolescents with T1D,
lower whole-kidney RO2:GFR associated with higher UACR (r=-0.31, p=0.03), RPF
(r=-0.52, p=0.0009) and fat mass (r=-0.33, p=0.02). Lower medullary RO2:GFR
associated with lower M/I (r=0.31, p=0.03). In conclusion, adolescents with T1D
exhibited relative renal hypoxia that associated with albuminuria, increased
RPF, fat mass, and insulin resistance. These data suggest a potential role of
renal hypoxia in the development of DKD.
|
|
|