Junguk Hur

Personal Information
Title Assistant Professor
Expertise Neuropathy & Neurocognition
Institution University of North Dakota
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Grants/SubContracts 1
Progress Reports 1
Publications 6
Protocols 0
Committees 1

Comparative Transcriptomics to Identify Key Gene Networks of Diabetic Neuropathy
Diabetes currently affects 29 million Americans, and the incidence is increasing by 5% per year. Diabetic peripheral neuropathy (DPN), the most common complication of diabetes, occurs in approximately 60% of all diabetic subjects. DPN is the leading cause of diabetes-related hospital admissions and non-traumatic amputations in the United States, there is substantial irreparable nerve damage prior to the development of noticeable symptoms. However, there are currently no disease-modifying treatments available for DPN other than glycemic control and symptomatic treatments for pain. Therefore, there is a critical need to identify novel effective therapies for DPN. The overall objectives of this proposal is (1) to identify crucial genes and pathways that underlie the progression of human DPN, and (2) to identify commonly dysregulated critical pathways in both human DPN and animal models of DPN. The rationale for the proposed research is that the identification of shared critical pathways and gene expression signatures between human and mouse DPN will elucidate the core mechanisms of DPN progression and expedite the development of mechanism-based therapeutic agents. We will accomplish the objectives of this proposal by pursuing the following specific aims: Aim 1. Identify dysregulated genes and pathways in human DPN using RNA-Seq. We previously reported that there are distinctive groups of human subjects with regenerative, stable, or degenerative DPN. We will use RNA-Seq to compare the transcriptomic signatures in sural nerves biopsies from subjects with regenerative DPN to subjects with degenerative DPN. Aim 2. Identify commonly dysregulated DPN-associated genes and pathways across species. We will compare the transcriptional regulatory network in human DPN with those identified in various mouse DPN models to provide insight into common pathways underlying DPN across species. We anticipate that the key genes and pathways highly correlated with DPN progression and conserved across species will play crucial roles in the pathogenesis of DPN and serve as primary targets of therapeutic intervention of DPN.

Progress Reports

Annual Reports
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Year: 2019; Items: 1

Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus.
Guo K, Elzinga S, Eid S, Figueroa-Romero C, Hinder LM, Pacut C, Feldman EL, Hur J
Epigenetics, 2019 (14), 766 - 779

Year: 2018; Items: 2

Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story.
Hinder LM, Murdock BJ, Park M, Bender DE, O'Brien PD, Rumora AE, Hur J, Feldman EL
Experimental neurology, 2018 (305), 33 - 43
Conserved Transcriptional Signatures in Human and Murine Diabetic Peripheral Neuropathy.
McGregor BA, Eid S, Rumora AE, Murdock B, Guo K, de Anda-Jáuregui G, Porter JE, Feldman EL, Hur J
Scientific reports, 2018 (8), 17678

Year: 2017; Items: 3

Comparative RNA-Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease.
Hinder LM, Park M, Rumora AE, Hur J, Eichinger F, Pennathur S, Kretzler M, Brosius FC, Feldman EL
Journal of cellular and molecular medicine, 2017
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission.
Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED
Circulation research, 2017
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