Sign-up for our newsletter
Protocols & Methods
Reagents & Resources
IMPC / KOMP Data
Transcriptional networks of progressive diabetic peripheral neuropathy in the
db/db mouse model of type 2 diabetes: An inflammatory story.
Hinder LM, Murdock BJ, Park M, Bender DE, O'Brien PD, Rumora AE, Hur J, Feldman
Junguk Hur on 11/5/2018
Volume : Pages
305 : 33 - 43
Diabetic peripheral neuropathy is the most common complication of diabetes and a
source of considerable morbidity. Numerous molecular pathways are linked to
neuropathic progression, but it is unclear whether these pathways are altered
throughout the course of disease. Moreover, the methods by which these molecular
pathways are analyzed can produce significantly different results; as such it is
often unclear whether previously published pathways are viable targets for novel
therapeutic approaches. In the current study we examine changes in gene
expression patterns in the sciatic nerve (SCN) and dorsal root ganglia (DRG) of
db/db diabetic mice at 8, 16, and 24?weeks of age using microarray analysis.
Following the collection and verification of gene expression data, we utilized
both self-organizing map (SOM) analysis and differentially expressed gene (DEG)
analysis to detect pathways that were altered at all time points. Though there
was some variability between SOM and DEG analyses, we consistently detected
altered immune pathways in both the SCN and DRG over the course of disease. To
support these results, we further used multiplex analysis to assess protein
changes in the SCN of diabetic mice; we found that multiple immune molecules
were upregulated at both early and later stages of disease. In particular, we
found that matrix metalloproteinase-12 was highly upregulated in microarray and
multiplex data sets suggesting it may play a role in disease progression.
Neuropathy & Neurocognition
Welcome to the DiaComp Login / Account Request Page.
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an External Scientific Panel member to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
There was a problem with the page:
Safari Browser Detected...
We strive to make the DiaComp site compatable with as many browsers as possible, but some of our third party tools don't work with the Safari browser.
In order to explore this site we highly recommend using the most recent versions of the following browsers:
© 2018 DiaComp.org
All rights reserved
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!