Charles Powell

Personal Information
Title Associate Professor
Expertise Uropathy
Institution Indiana University-Purdue University-Indianapolis
Data Summary
TypeCount
Grants/SubContracts 1
Progress Reports 1
Publications 5
Protocols 0
Committees 2
Experiments 0
Strains 1
Models 0

SubContract(s)


Progression of Diabetic Cystopathy in the Ossabaw Pig Using Bladder Monitor
Patients suffering from diabetes often have significant bladder complications, called diabetic cystopathy. This is diagnosed by clinical symptoms (LUTS, urinary incontinence, urinary retention) and bladder pressure measurements, called a urodynamic study. Unfortunately there are no methods to detect these changes at an early stage nor to measure progression over time. This is due to lack of a good animal model for diabetic cystopathy, and lack of technology to measure bladder pressure in-vivo over long periods of time. It is hypothesized that the diabetic bladder in the Ossabaw metabolic pig develops elevated storage pressure over time and this contributes to Lower Urinary Tract Symptoms (LUTS). A novel, ultrasound powered wireless bladder pressure measurement device can be implanted and will serve to measure pressures accurately over time to help explore this animal model. It is possible early detection will lead to early intervention and it may be possible to prevent this complication. Aim #1: We will document progression of diabetic cystopathy in the Ossabaw metabolic pig model through use of a novel ultrasound powered wireless implanted device to measure bladder pressure daily over 6 months. Bladder pressures will be compared to those measured in lean pigs (controls). Aim #2: The Ossabaw pig will be demonstrated as a valid animal model for the development of diabetic cystopathy. At the beginning and end of the 6 month study period a formal urodynamic study will be performed on the anesthetized pig to determine 1. Change in anesthetic bladder capacity (mL), 2. Increase in number of episodes of detrusor overactivity 3. Changes in bladder compliance. Serum creatinine and Blood Urea Nitrogen (BUN) content will also be assessed, as will fasting serum glucose (mg/dL) and glycosylated hemoglobin (Hgb A1c) as a measure of severity of diabetes. Bladder biopsies will also be taken. Aim #3: The investigators will demonstrate that the novel, ultrasound powered wireless bladder pressure sensor can accurately measure pressure over time, will not malfunction, and will not migrate out of the bladder or into the lumen of the bladder.


Progress Reports

Annual Reports

No uploaded documents found.

No uploaded documents found.

No protocols found.

No experiments found.

No models found.