Braden Kuo

Personal Information
Title Director
Expertise Gastro-Intestinal (GI)
Institution Massachusetts General Hospital
Data Summary
Grants/SubContracts 1
Progress Reports 0
Publications 1
Protocols 0
Committees 2


4D cine mri-assessed stomach motility in diabetic gastroparesis
Diabetic autonomic neuropathy is among the least recognized and understood complications of diabetes despite its significant negative impact on survival and quality of life. While validated cardiac clinical measures can document autonomic dysfunction, there are few tools to objectively assess autonomic dysfunction within the gastrointestinal tract. The most common clinical method of measuring gastric function, gastric emptying scintigraphy, has poor correlation with symptoms and other measures of autonomic dysfunction, in addition to requiring exposure to radiation. In this proposal, we will use a non-invasive, safe technique based on 4D cine magnetic resonance imaging (MRI), able to evaluate multiple aspects of gastric motor function simultaneously. Patients with diabetes mellitus gastroparesis (DMgp) will undergo gastric 4D cine-MRI, cardiac autonomic neuropathy testing, as well as a liquid meal challenge. We hypothesize that 1) MRI-assessed gastric function outcomes will correlate with clinical symptoms in DMgp patients following a test meal challenge, 2) DMgp patients will show altered gastric function compared to an existing cohort of age and sex-matched healthy control, and 3) gastric function outcomes will correlate with other cardiorespiratory autonomic metrics.

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