Krisztian Stadler

Personal Information
Title Associate Professor
Expertise Nephropathy
Institution Pennington Biomedical Research Center
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Grants/SubContracts 1
Progress Reports 1
Publications 4
Protocols 0
Committees 2

Reactive lipids in podocyte homeostasis
Early podocyte loss is characteristic of chronic kidney diseases, edpecially in diabetes and metabolic syndrome related nephropathies. Changes in the redox environment and redox imbalance have been implicated to play a role in podocyte loss, but the mechanisms are not well known. Reactive lipids and their end-products are an established biomarker in human diabetes, but it is not known how reactive lipids may influence podocyte homeostasis. The goal of our proposal is to understand the role of these reactive lipids in modulating podocyte survival signaling. The long term aim is to establish a role for these reactive species in the development of chronic kidney disesase and nephropathy. We have compelling preliminary data to propose that lipid radicals may fine tune podocyte response on an adaptive to maladaptive scale. While low levels of reactive lipids activate prosurvival mechanisms, higher levels may lead to pathology. The mechanisms involve redox sensitive control of rhoA to regulate podocyte motility and cytoskeletal rearrangements, and triggers to the slit diaphragm proteins - Akt axis to modulate survival signaling. To test this hypothesis, we will use in vitro and in vivo experiments, combined with our state of the art free radical approaches. In Aim 1, we will determine that reactive lipids serve as redox instigators of rhoA and survival mechanisms through Akt and podocyte specific proteins. In Aim 2, we will establish that specific scavenging of excess lipid radicals restores adaptive redox signaling in podocytes in vivo. Collectively, these aims will answer an important question - how lipid radicals may trigger podocyte survival or death and therefore how they contribute to podocyte defects and albuminuria. Outcomes from this proposal will advance the field by offering new avenues to targeted, redox based therapies, through understanding the mechanisms modulated by reactive lipids in podocytes.

Progress Reports
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Reactive lipids in podocyte homeostasis (Stadler, Krisztian)
10/30/2015View Progress Report Document
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 PublicationAltmetricsSubmitted ByPubMed IDStatus

Year: 2018; Items: 1

 
Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling.
Kruger C, Burke SJ, Collier JJ, Nguyen TT, Salbaum JM, Stadler K
Redox biology, 2018 (16), 248 - 254
29547847
Published

Year: 2015; Items: 3

 
The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease.
Stadler K, Goldberg IJ, Susztak K
Current diabetes reports, 2015 (15), 611
25957525
Published
 
Diet-induced obesity and kidney disease - In search of a susceptible mouse model.
Wicks SE, Nguyen TT, Breaux C, Kruger C, Stadler K
Biochimie, 2015
26248309
Published
 
IL-1ß reciprocally regulates chemokine and insulin secretion in pancreatic ß-cells via NF-?B.
Burke SJ, Stadler K, Lu D, Gleason E, Han A, Donohoe DR, Rogers RC, Hermann GE, Karlstad MD, Collier JJ
American journal of physiology. Endocrinology and metabolism, 2015 (309), E715 - 26
26306596
Published
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