Genetics of diabetic nephropathy: lessons from mice.
Authors Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Zhao HJ, Harris RC
Submitted By Raymond Harris on 11/6/2007
Status Published
Journal Seminars in nephrology
Year 2007
Date Published 3/1/2007
Volume : Pages 27 : Not Specified
PubMed Reference 17418691
Abstract Although diabetic nephropathy occurs only in a minority of diabetic patients
(approximately 30%), it is the major single cause of end-stage renal disease in
the United States. Hyperglycemia and hypertension are important factors
predisposing patients to nephropathy, however, accumulating evidence points to
critical genetic factors that predispose only a subset of diabetic patients to
nephropathy. Defining the genes responsible for nephropathy risk in human
populations has proven challenging. Comparative genomics using the robust
genetic reagents available in the laboratory mouse should provide a
complementary approach to defining genes that may predispose to diabetic
nephropathy in mice and human beings. In this article we review studies that
have started to identify genetic risk factors for diabetic nephropathy in mice
and the multiple approaches that may be used to elucidate the genetic
pathogenesis of this disorder.

Investigators with authorship
Matthew BreyerJohnson & Johnson
Agnes FogoVanderbilt University
Raymond HarrisVanderbilt University
Takamune TakahashiVanderbilt University