Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular
Function in Young Adults.
Authors Pichler G, Grau-Perez M, Tellez-Plaza M, Umans J, Best L, Cole S, Goessler W,
Francesconi K, Newman J, Redon J, Devereux R, Navas-Acien A
Submitted By Jonathan Newman on 10/14/2019
Status Published
Journal Circulation. Cardiovascular imaging
Year 2019
Date Published 5/1/2019
Volume : Pages 12 : e009018
PubMed Reference 31060373
Abstract Arsenic exposure has been related to numerous adverse cardiovascular outcomes.
The aim of this study was to investigate the cross-sectional and prospective
association between arsenic exposure with echocardiographic measures of left
ventricular (LV) geometry and functioning., A total of 1337 young adult
participants free of diabetes mellitus and cardiovascular disease were recruited
from the SHFS (Strong Heart Family Study). The sum of inorganic and methylated
arsenic concentrations in urine (SAs) at baseline was used as a biomarker of
arsenic exposure. LV geometry and functioning were assessed using transthoracic
echocardiography at baseline and follow-up., Mean follow-up was 5.6 years, and
median (interquartile range) of SAs was 4.2 (2.8-6.9) µg/g creatinine. Increased
arsenic exposure was associated with prevalent LV hypertrophy, with an odds
ratio (95% CI) per a 2-fold increase in SAs of 1.47 (1.05-2.08) in all
participants and of 1.58 (1.04-2.41) among prehypertensive or hypertensive
individuals. Measures of LV geometry, including LV mass index, left atrial
systolic diameter, interventricular septum, and LV posterior wall thickness,
were positively and significantly related to arsenic exposure. Among measures of
LV functioning, stroke volume, and ejection fraction were associated with
arsenic exposure., Arsenic exposure was related to an increase in LV wall
thickness and LV hypertrophy in young American Indians with a low burden of
cardiovascular risk factors. The relationship was stronger in participants with
prehypertension or hypertension, suggesting that potential cardiotoxic effects
of arsenic might be more pronounced in individuals already undergoing
cardiovascular adaptive mechanisms following elevated systemic blood pressure.