Lipid Mediators of Insulin Signaling in Diabetic Kidney Disease.
Authors Mitrofanova A, Sosa MA, Fornoni A
Submitted By Alessia Fornoni on 10/14/2019
Status Published
Journal American journal of physiology. Renal physiology
Year 2019
Date Published 9/1/2019
Volume : Pages Not Specified : Not Specified
PubMed Reference 31545927
Abstract Diabetic kidney disease (DKD) affects approximately 40% of patients with
diabetes and is associated with high mortality rates. Among different cellular
targets in DKD, podocytes, a highly specialized epithelial cells of the
glomerular filtration barrier, are injured in the early stages of DKD. Both
clinical and experimental data support the role of preserved insulin signaling
as a major contributor to podocyte function and survival. However, little is
known about the key modulators of podocyte insulin signaling. This review
summarizes the novel knowledge that intracellular lipids such as cholesterol and
sphingolipids are major determinants of podocyte insulin signaling. In
particular, the implications of these lipids on DKD development, progression and
treatment will be addressed.