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Lipid Mediators of Insulin Signaling in Diabetic Kidney Disease.
Mitrofanova A, Sosa MA, Fornoni A
Alessia Fornoni on 10/14/2019
American journal of physiology. Renal physiology
Volume : Pages
Diabetic kidney disease (DKD) affects approximately 40% of patients with
diabetes and is associated with high mortality rates. Among different cellular
targets in DKD, podocytes, a highly specialized epithelial cells of the
glomerular filtration barrier, are injured in the early stages of DKD. Both
clinical and experimental data support the role of preserved insulin signaling
as a major contributor to podocyte function and survival. However, little is
known about the key modulators of podocyte insulin signaling. This review
summarizes the novel knowledge that intracellular lipids such as cholesterol and
sphingolipids are major determinants of podocyte insulin signaling. In
particular, the implications of these lipids on DKD development, progression and
treatment will be addressed.
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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