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Publication

Mice with cardiac overexpression of peroxisome proliferator-activated receptor ? have impaired repolarization and spontaneous fatal ventricular arrhythmias.

Authors Morrow JP, Katchman A, Son NH, Trent CM, Khan R, Shiomi T, Huang H, Amin V, Lader JM, Vasquez C, Morley GE, D'Armiento J, Homma S, Goldberg IJ, Marx SO Submitted By Ira Goldberg on 2/22/2012 Status Published Journal Circulation Year 2011 Date Published 12/20/2011 Volume : Pages 124 : 2812 - 2821 PubMed Reference 22124376 Abstract Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the contribution of global metabolic defects to the increased incidence of sudden death and electric abnormalities.

Investigators with authorship
Name Institution Ira Goldberg New York University School of Medicine

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