Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation
and increased hepatic glucose production in a mouse model of hereditary
Authors Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, Cooksey RC, McClain DA
Submitted By E. Dale Abel on 2/22/2012
Status Published
Journal Diabetes
Year 2011
Date Published 1/1/2011
Volume : Pages 60 : 80 - 87
PubMed Reference 20876715
Abstract Excess tissue iron levels are a risk factor for diabetes, but the mechanisms
underlying the association are incompletely understood. We previously published
that mice and humans with a form of hereditary iron overload, hemochromatosis,
exhibit loss of ß-cell mass. This effect by itself is not sufficient, however,
to fully explain the diabetes risk phenotype associated with all forms of iron

Investigators with authorship
E. Dale AbelUniversity of Iowa