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Publication

Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.

Authors Pendse AA, Johnson LA, Tsai YS, Maeda N Submitted By Nobuyo Maeda on 5/2/2011 Status Published Journal Diabetes Year 2010 Date Published 11/1/2010 Volume : Pages 59 : 2890 - 2897 PubMed Reference 20724579 Abstract The dominant-negative P467L mutation in peroxisome proliferator activated receptor-? (PPAR?) was identified in insulin-resistant patients with hyperglycemia and lipodystrophy. In contrast, mice carrying the corresponding Pparg-P465L mutation have normal insulin sensitivity, with mild hyperinsulinemia. We hypothesized that murine Pparg-P465L mutation leads to covert insulin resistance, which is masked by hyperinsulinemia and increased pancreatic islet mass, to retain normal plasma glucose.

Investigators with authorship
Name Institution Nobuyo Maeda University of North Carolina

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