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The glomerular podocyte as a target of growth hormone action: implications for
the pathogenesis of diabetic nephropathy.
Kumar PA, Brosius FC, Menon RK
Frank Brosius on 5/2/2011
Current diabetes reviews
Volume : Pages
7 : 50 - 55
Involvement of the growth hormone (GH) / insulin-like growth factor 1 (IGF-I)
axis in the pathogenesis of diabetic nephropathy (DN) is strongly suggested by
studies investigating the impact of GH excess and deficiency on renal structure
and function. GH excess in both the human (acromegaly) and in transgenic animal
models is characterized by significant structural and functional changes in the
kidney. In the human a direct relationship has been noted between the activity
of the GH/IGF-1 axis and renal hypertrophy, microalbuminuria, and
glomerulosclerosis. Conversely, states of GH deficiency or deficiency or
inhibition of GH receptor (GHR) activity confer a protective effect against DN.
The glomerular podocyte plays a central and critical role in the structural and
functional integrity of the glomerular filtration barrier and maintenance of
normal renal function. Recent studies have revealed that the glomerular podocyte
is a target of GH action and that GH's actions on the podocyte could be
detrimental to the structure and function of the podocyte. These results provide
a novel mechanism for GH's role in the pathogenesis of DN and offer the
possibility of targeting the GH/IGF-1 axis for the prevention and treatment of
Investigators with authorship
University of Arizona
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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