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Genomic strategies for diabetic nephropathy.
Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP
Erwin Bottinger on 5/2/2011
Journal of the American Society of Nephrology : JASN
Volume : Pages
14 : S271 - S278
Insight into the molecular mechanisms that underlie the origin and progression
of diabetic nephropathy remains limited in part because conventional research
tools have restricted investigators to focus on single genes or isolated
pathways. Microarray technologies provide opportunities for evaluating genetic
factors and environmental effects at a genomic scale during the pathogenesis of
diabetic nephropathy. Despite the enormous power of the microarray technology,
there are several pitfalls that need to be considered. This article discusses
conceptual, practical, statistical, and logistical considerations for the use of
microarrays in studies of experimental and human diabetic renal disease. New
knowledge in this field will facilitate new approaches for molecular diagnosis
and drug discovery.
Investigators with authorship
Mount Sinai School of Medicine
University of California San Diego
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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