Genomic strategies for diabetic nephropathy.
Authors Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP
Submitted By Erwin Bottinger on 5/2/2011
Status Published
Journal Journal of the American Society of Nephrology : JASN
Year 2003
Date Published 8/1/2003
Volume : Pages 14 : S271 - S278
PubMed Reference 12874445
Abstract Insight into the molecular mechanisms that underlie the origin and progression
of diabetic nephropathy remains limited in part because conventional research
tools have restricted investigators to focus on single genes or isolated
pathways. Microarray technologies provide opportunities for evaluating genetic
factors and environmental effects at a genomic scale during the pathogenesis of
diabetic nephropathy. Despite the enormous power of the microarray technology,
there are several pitfalls that need to be considered. This article discusses
conceptual, practical, statistical, and logistical considerations for the use of
microarrays in studies of experimental and human diabetic renal disease. New
knowledge in this field will facilitate new approaches for molecular diagnosis
and drug discovery.

Investigators with authorship
Erwin BottingerMount Sinai School of Medicine
Richard McIndoeAugusta University
Kumar SharmaUniversity of California San Diego