Mitochondria in the diabetic heart.
Authors Bugger H, Abel ED
Submitted By E. Dale Abel on 5/2/2011
Status Published
Journal Cardiovascular research
Year 2010
Date Published 11/1/2010
Volume : Pages 88 : 229 - 240
PubMed Reference 20639213
Abstract Diabetes mellitus increases the risk of developing cardiovascular diseases such
as coronary artery disease and heart failure. Studies have shown that the heart
failure risk is increased in diabetic patients even after adjusting for coronary
artery disease and hypertension. Although the cause of this increased heart
failure risk is multifactorial, increasing evidence suggests that derangements
in cardiac energy metabolism play an important role. In particular,
abnormalities in cardiomyocyte mitochondrial energetics appear to contribute
substantially to the development of cardiac dysfunction in diabetes. This review
will summarize these abnormalities in mitochondrial function and discuss
potential underlying mechanisms.

Investigators with authorship
E. Dale AbelUniversity of Iowa