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Publication
Mitochondria in the diabetic heart.
Authors
Bugger H, Abel ED
Submitted By
E. Dale Abel on 5/2/2011
Status
Published
Journal
Cardiovascular research
Year
2010
Date Published
11/1/2010
Volume : Pages
88 : 229 - 240
PubMed Reference
20639213
Abstract
Diabetes mellitus increases the risk of developing cardiovascular diseases such
as coronary artery disease and heart failure. Studies have shown that the heart
failure risk is increased in diabetic patients even after adjusting for coronary
artery disease and hypertension. Although the cause of this increased heart
failure risk is multifactorial, increasing evidence suggests that derangements
in cardiac energy metabolism play an important role. In particular,
abnormalities in cardiomyocyte mitochondrial energetics appear to contribute
substantially to the development of cardiac dysfunction in diabetes. This review
will summarize these abnormalities in mitochondrial function and discuss
potential underlying mechanisms.
Investigators with authorship
Name
Institution
E. Dale Abel
University of Iowa
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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