Rodent models of diabetic cardiomyopathy.
Authors Bugger H, Abel ED
Submitted By E. Dale Abel on 4/26/2010
Status Published
Journal Disease models & mechanisms
Year 2009
Date Published 12/1/2009
Volume : Pages 2 : 454 - 466
PubMed Reference 19726805
Abstract Diabetic cardiomyopathy increases the risk of heart failure in individuals with
diabetes, independently of co-existing coronary artery disease and hypertension.
The underlying mechanisms for this cardiac complication are incompletely
understood. Research on rodent models of type 1 and type 2 diabetes, and the use
of genetic engineering techniques in mice, have greatly advanced our
understanding of the molecular mechanisms responsible for human diabetic
cardiomyopathy. The adaptation of experimental techniques for the investigation
of cardiac physiology in mice now allows comprehensive characterization of these
models. The focus of the present review will be to discuss selected rodent
models that have proven to be useful in studying the underlying mechanisms of
human diabetic cardiomyopathy, and to provide an overview of the characteristics
of these models for the growing number of investigators who seek to understand
the pathology of diabetes-related heart disease.

Investigators with authorship
E. Dale AbelUniversity of Iowa