Lipotoxicity in the heart.
Authors Wende AR, Abel ED
Submitted By E. Dale Abel on 4/25/2010
Status Published
Journal Biochimica et biophysica acta
Year 2010
Date Published 3/1/2010
Volume : Pages 1801 : 311 - 319
PubMed Reference 19818871
Abstract Obesity and insulin resistance are associated with ectopic lipid deposition in
multiple tissues, including the heart. Excess lipid may be stored as
triglycerides, but are also shunted into non-oxidative pathways that disrupt
normal cellular signaling leading to organ dysfunction and in some cases
apoptosis, a process termed lipotoxicity. Various pathophysiological mechanisms
have been proposed to lead to lipotoxic tissue injury, which might vary by cell
type. Specific mechanisms by which lipotoxicity alter cardiac structure and
function are incompletely understood, but are beginning to be elucidated. This
review will focus on mechanisms that have been proposed to lead to lipotoxic
injury in the heart and will review the state of knowledge regarding potential
causes and correlates of increased myocardial lipid content in animal models and
humans. We will seek to highlight those areas where additional research is

Investigators with authorship
E. Dale AbelUniversity of Iowa