Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the
roles of fetuin-A, adiponectin, and AMPK.
Authors Ix JH, Sharma K
Submitted By Kumar Sharma on 3/24/2010
Status Published
Journal Journal of the American Society of Nephrology : JASN
Year 2010
Date Published 3/1/2010
Volume : Pages 21(3) : 406 - 412
PubMed Reference 20150538
Abstract Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty
liver disease (NAFLD). Recent studies identify mechanisms common to both
diseases linked through an interorgan communication orchestrated by fetuin-A and
adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein
kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory
and potentially deleterious pathways, leading to inflammatory and profibrotic
cascades culminating in end-organ damage. Regulation of these early upstream
pathways may provide new therapeutic targets for these increasingly common
sequelae of obesity.

Investigators with authorship
Kumar SharmaUniversity of California San Diego


Map3k14mitogen-activated protein kinase kinase kinase 14
Adipoqadiponectin, C1Q and collagen domain containing