Sign-up for our newsletter

Publication

Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Authors Sihem Boudina and E. Dale Abel Submitted By E. Dale Abel on 9/24/2007 Status Published Journal Physiology (Bethesda, Md.) Year 2006 Date Published 8/1/2006 Volume : Pages 21 : 250 - 258 PubMed Reference 16868314 Abstract Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.

Investigators with authorship
Name Institution E. Dale Abel University of Iowa

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing