Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in
Authors Sihem Boudina and E. Dale Abel
Submitted By E. Dale Abel on 9/24/2007
Status Published
Journal Physiology (Bethesda, Md.)
Year 2006
Date Published 8/1/2006
Volume : Pages 21 : 250 - 258
PubMed Reference 16868314
Abstract Cardiovascular disease is the primary cause of death in individuals with obesity
diabetes. However, the underlying mechanisms for cardiac dysfunction are
understood. Studies have suggested that altered cardiac metabolism may play a
role. The diabetic heart is characterized by increased fatty acid oxidation,
increased myocardial oxygen consumption, and reduced cardiac efficiency. Here,
we review possible mechanisms for reduced cardiac efficiency in obesity and
diabetes by focusing on the potential role of mitochondrial uncoupling.

Investigators with authorship
E. Dale AbelUniversity of Iowa