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Publication

Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy.

Authors Xu L, Hiller S, Simington S, Nickeleit V, Maeda N, James LR, Yi X Submitted By Xianwen Yi on 10/12/2016 Status Published Journal PLoS ONE Year 2016 Date Published Volume : Pages 11 : Not Specified PubMed Reference 27706190 Abstract Oxidative stress is implicated in the pathogenesis of diabetic nephropathy (DN) but outcomes of many clinical trials are controversial. To define the role of antioxidants in kidney protection during the development of diabetic nephropathy, we have generated a novel genetic antioxidant mouse model with over- or under-expression of lipoic acid synthase gene (Lias). These models have been mated with Ins2Akita/+ mice, a type I diabetic mouse model. We compare the major pathologic changes and oxidative stress status in two new strains of the mice with controls. Our results show that Ins2Akita/+ mice with under-expressed Lias gene, exhibit higher oxidative stress and more severe DN features (albuminuria, glomerular basement membrane thickening and mesangial matrix expansion). In contrast, Ins2Akita/+ mice with highly-expressed Lias gene display lower oxidative stress and less DN pathologic changes. Our study demonstrates that strengthening endogenous antioxidant capacity could be an effective strategy for prevention and treatment of DN.

Investigators with authorship
Name Institution Nobuyo Maeda University of North Carolina Xianwen Yi University of North Carolina at Chapel Hill

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing