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Publication

Circulating TGF-ß1-regulated miRNAs and the risk of rapid progression to ESRD in type 1 diabetes.

Authors Pezzolesi MG, Satake E, McDonnell KP, Major M, Smiles AM, Krolewski AS Submitted By Marcus Pezzolesi on 5/10/2015 Status Published Journal Diabetes Year 2015 Date Published 4/30/2015 Volume : Pages Not Specified : Not Specified PubMed Reference 25931475 Abstract We investigated whether circulating TGF-ß1-regulated miRNAs detectable in plasma are associated with the risk of rapid progression to end-stage renal disease (ESRD) in a cohort of proteinuric patients with type 1 diabetes (T1D) and normal eGFR. Plasma specimens obtained at entry to the study were examined in two prospective sub-groups that were followed for 7-20 years (rapid progressors and non-progressors), as well as a reference panel of normoalbuminuric T1D patients.Of the 5 miRNAs examined in this study, let-7c-5p and miR-29a-3p were significantly associated with protection against rapid progression and let-7b-5p and miR-21-5p were significantly associated with the increased risk of ESRD. In logistic analysis, controlling for HbA1c and other covariates, let-7c-5p and miR-29a-3p were associated with more than a 50% reduction in the risk of rapid progression (P = 0.001), while let-7b-5p and miR-21-5p were associated with a >2.5-fold increase in the risk of ESRD (P = 0.005).This study is the first prospective study to demonstrate that circulating TGF-ß1-regulated miRNAs are deregulated early in T1D patients who are at risk of rapid progression to ESRD.

Investigators with authorship
Name Institution Marcus Pezzolesi University of Utah

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