Pro- and antiatherogenic effects of a dominant-negative P465L mutation of
peroxisome proliferator-activated receptor-? in apolipoprotein E-Null mice.
Authors Pendse AA, Johnson LA, Kim HS, McNair M, Nipp CT, Wilhelm C, Maeda N
Submitted By Nobuyo Maeda on 3/4/2015
Status Published
Journal Arteriosclerosis, thrombosis, and vascular biology
Year 2012
Date Published 6/1/2012
Volume : Pages 32 : 1436 - 1444
PubMed Reference 22539598
Abstract The dominant-negative mutation, P467L, in peroxisome proliferator-activated
receptor-? (PPAR?) affects adipose tissue distribution, insulin sensitivity, and
blood pressure in heterozygous humans. We hypothesized that the equivalent
mutation, PPAR?-P465L, in mice will worsen atherosclerosis.

Investigators with authorship
Nobuyo MaedaUniversity of North Carolina