Modulation of the cardiovascular system by leptin.
Authors Abel ED, Sweeney G
Submitted By E. Dale Abel on 3/4/2015
Status Published
Journal Biochimie
Year 2012
Date Published 10/1/2012
Volume : Pages 94 : 2097 - 2103
PubMed Reference 22490727
Abstract It is well established that individuals with the metabolic syndrome have a
significantly increased risk of cardiovascular disease and much effort has been
expended to elicit the underlying mechanisms. Various studies have proposed that
excessive or deficient physiological effects mediated by leptin make an
important contribution, yet many paradoxical observations often preclude a clear
definition of the role of leptin. This review article will briefly discuss
principal and most recent evidence on direct and indirect regulation of the
cardiovascular system by leptin, focusing on cardiac structural and functional
as well as vascular effects.

Investigators with authorship
E. Dale AbelUniversity of Iowa