Sign-up for our newsletter

Publication

Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model.

Authors Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F Submitted By Florin Despa on 1/6/2015 Status Published Journal Journal of the American Heart Association Year 2014 Date Published 8/1/2014 Volume : Pages 3 : Not Specified PubMed Reference 25146704 Abstract Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investigated whether amylin aggregates interact directly with cardiac myocytes and whether controlling hyperamylinemia protects the heart.

Investigators with authorship
Name Institution Florin Despa University of Kentucky

Complications
All Complications Bioinformatics Bone Cardiomyopathy Cardiovascular Gastro-Intestinal (GI) Nephropathy Neuropathy & Neurocognition Pediatric Endocrinology Retinopathy Uropathy Wound Healing