MRI-detectable nanoparticles: the potential role in the diagnosis of and therapy
for chronic kidney disease.
Authors Charlton JR, Beeman SC, Bennett KM
Submitted By Kevin Bennett on 12/8/2014
Status Published
Journal Advances in chronic kidney disease
Year 2013
Date Published 11/1/2013
Volume : Pages 20 : 479 - 487
PubMed Reference 24206600
Abstract Chronic kidney disease (CKD) is a common, deadly, and expensive threat to public
health. Patients susceptible to the development of CKD are difficult to identify
because there are few noninvasive clinical techniques and markers to assess
early kidney dysfunction. Noninvasive imaging techniques are being developed to
quantitatively measure kidney morphology and function in preclinical research
and in clinical trials. Magnetic resonance imaging (MRI) techniques in
particular have the potential to provide structural and functional information
in the kidney. Novel molecular imaging techniques, using targeted magnetic
nanoparticles that exploit the characteristics of the endogenous protein,
ferritin, have been developed in conjunction with MRI to count every perfused
glomerulus in the kidney and measure their individual volumes. This technique
could open the door to the possibility of prospectively assessing and eventually
reducing a patient's risk for progression to CKD. This review highlights the
potential clinical benefits of early detection in patients predisposed to CKD
and discusses technologic and regulatory hurdles to the translation of these
molecular MRI techniques to provide early diagnosis of CKD.

Investigators with authorship
Kevin BennettWashington University in St Louis