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Publication

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin.

Authors Srodulski S, Sharma S, Bachstetter AB, Brelsfoard JM, Pascual C, Xie XS, Saatman KE, Van Eldik LJ, Despa F Submitted By Florin Despa on 8/28/2014 Status Published Journal Molecular neurodegeneration Year 2014 Date Published Volume : Pages 9 : 30 PubMed Reference 25149184 Abstract We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone synthesized and co-secreted with insulin by pancreatic ß-cells. Amylin deposition is promoted by chronic hypersecretion of amylin (hyperamylinemia), which is common in humans with obesity or pre-diabetic insulin resistance. Human amylin oligomerizes quickly when oversecreted, which is toxic, induces inflammation in pancreatic islets and contributes to the development of T2D. Here, we tested the hypothesis that accumulation of oligomerized amylin affects brain function.

Investigators with authorship
Name Institution Florin Despa University of Kentucky

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