Phenotyping animal models of diabetic neuropathy: a consensus statement of the
diabetic neuropathy study group of the EASD (Neurodiab).
Authors The Working Group of Neurodiab, Biessels GJ, Bril V, Calcutt NA, Cameron NE,
Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin
AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt
RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D,
Zochodne DW
Submitted By Nigel Calcutt on 6/23/2014
Status Published
Journal Journal of the peripheral nervous system : JPNS
Year 2014
Date Published 6/17/2014
Volume : Pages 19 : 77 - 87
PubMed Reference 24934510
Abstract NIDDK, JDRF, and the Diabetic Neuropathy Study Group of EASD sponsored a meeting
to explore the current status of animal models of diabetic peripheral
neuropathy. The goal of the workshop was to develop a set of consensus criteria
for the phenotyping of rodent models of diabetic neuropathy. The discussion was
divided into five areas: 1) status of commonly used rodent models of diabetes,
2) nerve structure, 3) electrophysiological assessments of nerve function, 4)
behavioral assessments of nerve function, and 5) the role of biomarkers in
disease phenotyping. Participants discussed the current understanding of each
area, gold standards (if applicable) for assessments of function, improvements
of existing techniques, and utility of known and exploratory biomarkers. The
research opportunities in each area were outlined, providing a possible roadmap
for future studies. The meeting concluded with a discussion on the merits and
limitations of a unified approach to phenotyping rodent models of diabetic
neuropathy and a consensus formed on the definition of the minimum criteria
required for establishing the presence of the disease. A neuropathy phenotype in
rodents was defined as the presence of statistically different values between
diabetic and control animals in 2 of 3 assessments (nocifensive behavior, nerve
conduction velocities or nerve structure). The participants propose that this
framework would allow different research groups to compare and share data, with
an emphasis on data targeted towards the therapeutic efficacy of drug

Investigators with authorship
Nigel CalcuttUniversity of California San Diego
Richard McIndoeAugusta University