Molecular mechanisms of diabetic cardiomyopathy.
Authors Bugger H, Abel ED
Submitted By E. Dale Abel on 4/15/2014
Status Published
Journal Diabetologia
Year 2014
Date Published 4/1/2014
Volume : Pages 57 : 660 - 671
PubMed Reference 24477973
Abstract In recent years, diabetes mellitus has become an epidemic and now represents one
of the most prevalent disorders. Cardiovascular complications are the major
cause of mortality and morbidity in diabetic patients. While ischaemic events
dominate the cardiac complications of diabetes, it is widely recognised that the
risk for developing heart failure is also increased in the absence of overt
myocardial ischaemia and hypertension or is accelerated in the presence of these
comorbidities. These diabetes-associated changes in myocardial structure and
function have been called diabetic cardiomyopathy. Numerous molecular mechanisms
have been proposed to contribute to the development of diabetic cardiomyopathy
following analysis of various animal models of type 1 or type 2 diabetes and in
genetically modified mouse models. The steady increase in reports presenting
novel mechanistic data on this subject expands the list of potential underlying
mechanisms. The current review provides an update on molecular alterations that
may contribute to the structural and functional alterations in the diabetic

Investigators with authorship
E. Dale AbelUniversity of Iowa