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Biology of diabetic neuropathy.
Vincent AM, Calabek B, Roberts L, Feldman EL
Eva Feldman on 4/15/2014
Handbook of clinical neurology
Volume : Pages
115 : 591 - 606
More than half of all patients with diabetes develop neuropathic disorders
affecting the distal sensory and/or motor nerves, or autonomic or cranial nerve
functions. Glycemic control can decrease the incidence of neuropathy but is not
adequate alone to prevent or treat the disease. This chapter introduces diabetic
neuropathy with a morphological description of the disease then describes our
current understanding of metabolic and molecular mechanisms that contribute to
neurovascular dysfunctions. Key mechanisms include glucose and lipid imbalances
and insulin resistance that are interconnected via oxidative stress,
inflammation, and altered gene expression. These complex interactions should be
considered for the development of new treatment strategies against the onset or
progression of neuropathy. Advances in understanding the combined metabolic
stressors and the novel study of epigenetics suggest new therapeutic targets to
combat this morbid and intractable disease affecting millions of patients with
type 1 or type 2 diabetes.
Investigators with authorship
University of Michigan
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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