Glomerular Disease: Looking beyond Pathology.
Authors Wiggins RC, Alpers CE, Holzman LB, He JC, Salant DJ, Chugh SS, Natarajan R,
Trachtman H, Brasile L, Star RA, Rys-Sikora KE, Moxey-Mims MM, Flessner MF
Submitted By Submitted Externally on 4/15/2014
Status Published
Journal Clinical journal of the American Society of Nephrology : CJASN
Year 2014
Date Published 4/3/2014
Volume : Pages 9 : 1138 - 1140
PubMed Reference 24700796
Abstract The National Institute of Diabetes and Digestive and Kidney Diseases-supported
Kidney Research National Dialogue asked the scientific community to formulate
and prioritize research objectives aimed at improved understanding of kidney
function and disease progression. Over the past 2 years, 1600 participants
posted almost 300 ideas covering all areas of kidney disease. An overriding
theme that evolved through these discussions is the need to move beyond
pathology to take advantage of basic science and clinical research opportunities
to improve diagnostic classification and therapeutic options for people with
primary glomerular disease. High-priority research areas included focus on
therapeutic targets in glomerular endothelium and podocytes, regenerating
podocytes through developmental pathways, use of longitudinal phenotypically
defined disease cohorts to improve classification schemes, identifying
biomarkers, disease-specific therapeutics, autoantibody triggers, and changing
the clinical research culture to promote participation in clinical trials.
Together, these objectives provide a path forward for improving clinical
outcomes of glomerular disease.

Investigators with authorship
Charles AlpersUniversity of Washington
Lawrence HolzmanUniversity of Pennsylvania