TNF-a signals through PKC?/NF-?B to alter the tight junction complex and
increase retinal endothelial cell permeability.
Authors Aveleira CA, Lin CM, Abcouwer SF, Ambrósio AF, Antonetti DA
Submitted By Submitted Externally on 4/15/2014
Status Published
Journal Diabetes
Year 2010
Date Published 11/1/2010
Volume : Pages 59 : 2872 - 2882
PubMed Reference 20693346
Abstract Tumor necrosis factor-a (TNF-a) and interleukin-1 beta (IL-1ß) are elevated in
the vitreous of diabetic patients and in retinas of diabetic rats associated
with increased retinal vascular permeability. However, the molecular mechanisms
underlying retinal vascular permeability induced by these cytokines are poorly
understood. In this study, the effects of IL-1ß and TNF-a on retinal endothelial
cell permeability were compared and the molecular mechanisms by which TNF-a
increases cell permeability were elucidated.

Investigators with authorship
Steven AbcouwerUniversity of Michigan-Ann Arbor