An integrated approach to diabetic retinopathy research.
Authors Gardner TW, Abcouwer SF, Barber AJ, Jackson GR
Submitted By Submitted Externally on 4/15/2014
Status Published
Journal Archives of ophthalmology
Year 2011
Date Published 2/1/2011
Volume : Pages 129 : 230 - 235
PubMed Reference 21320973
Abstract This review discusses the pathophysiology of diabetic retinopathy related to
direct effects of loss of insulin receptor action and metabolic dysregulation on
the retina. The resulting sensory neuropathy can be diagnosed by structural and
functional tests in patients with mild nonproliferative diabetic retinopathy.
Research teams can collaborate to integrate ocular and systemic factors that
impair vision and to design strategies to maintain retinal function in persons
with diabetes mellitus. Evolving concepts may lead to inclusion of tests of
retinal function in the detection of diabetic retinopathy and neuroprotective
strategies to preserve vision for persons with diabetes.

Investigators with authorship
Steven AbcouwerUniversity of Michigan-Ann Arbor
Alistair BarberPennsylvania State University-Penn State College of Medicine