Human aldose reductase expression accelerates atherosclerosis in diabetic
apolipoprotein E-/- mice.
Authors Vedantham S, Noh H, Ananthakrishnan R, Son N, Hallam K, Hu Y, Yu S, Shen X,
Rosario R, Lu Y, Ravindranath T, Drosatos K, Huggins LA, Schmidt AM, Goldberg
IJ, Ramasamy R
Submitted By Submitted Externally on 3/17/2014
Status Published
Journal Arteriosclerosis, thrombosis, and vascular biology
Year 2011
Date Published 8/1/2011
Volume : Pages 31 : 1805 - 1813
PubMed Reference 21636809
Abstract There are several pathways that mediate the aberrant metabolism of glucose and
that might induce greater vascular damage in the setting of diabetes. The polyol
pathway mediated by aldose reductase (AR) has been postulated to be one such
pathway. However, it has been reported that AR reduces toxic lipid aldehydes
and, under some circumstances, might be antiatherogenic.

Investigators with authorship
Ira GoldbergNew York University School of Medicine