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Publication

Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice.

Authors Vedantham S, Noh H, Ananthakrishnan R, Son N, Hallam K, Hu Y, Yu S, Shen X, Rosario R, Lu Y, Ravindranath T, Drosatos K, Huggins LA, Schmidt AM, Goldberg IJ, Ramasamy R Submitted By Submitted Externally on 3/17/2014 Status Published Journal Arteriosclerosis, thrombosis, and vascular biology Year 2011 Date Published 8/1/2011 Volume : Pages 31 : 1805 - 1813 PubMed Reference 21636809 Abstract There are several pathways that mediate the aberrant metabolism of glucose and that might induce greater vascular damage in the setting of diabetes. The polyol pathway mediated by aldose reductase (AR) has been postulated to be one such pathway. However, it has been reported that AR reduces toxic lipid aldehydes and, under some circumstances, might be antiatherogenic.

Investigators with authorship
Name Institution Ira Goldberg New York University School of Medicine

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