NRF2 plays a protective role in diabetic retinopathy in mice.
Authors Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa
JT, Du Y, Kern TS, Thimmulappa R, Barber AJ, Biswal S, Duh EJ
Submitted By Submitted Externally on 3/17/2014
Status Published
Journal Diabetologia
Year 2014
Date Published 1/1/2014
Volume : Pages 57 : 204 - 213
PubMed Reference 24186494
Abstract Although much is known about the pathophysiological processes contributing to
diabetic retinopathy (DR), the role of protective pathways has received less
attention. The transcription factor nuclear factor erythroid-2-related factor 2
(also known as NFE2L2 or NRF2) is an important regulator of oxidative stress and
also has anti-inflammatory effects. The objective of this study was to explore
the potential role of NRF2 as a protective mechanism in DR.

Investigators with authorship
Alistair BarberPennsylvania State University-Penn State College of Medicine