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Angiogenic Factors and Cytokines in Diabetic Retinopathy.
Steven Abcouwer on 3/17/2014
Journal of clinical & cellular immunology
Volume : Pages
Suppl 1 :
Diabetic retinopathy (DR) is a sight-threatening complication of both type-1 and
type-2 diabetes. The recent success of treatments inhibiting the function of
vascular endothelial growth factor (VEGF) demonstrates that specific targeting
of a growth factor responsible for vascular permeability and growth is an
effective means of treating DR-associated vascular dysfunction, edema and
angiogenesis. This has stimulated research of alternative therapeutic targets
involved in the control of retinal vascular function. However, additional
treatment options and preventative measures are still needed and these require a
greater understanding of the pathological mechanisms leading to the disturbance
of retinal tissue homeostasis in DR. Although severe DR can be treated as a
vascular disease, abundant data suggests that inflammation is also occurring in
the diabetic retina.Thus, anti-inflammatory therapies may also be useful for
treatment and prevention of DR. Herein, the evidence for altered expression of
angiogenic factors and cytokines in DR is reviewed and possible mechanisms by
which the expression of VEGF and cytokines may be increased in the diabetic
retina are examined. In addition, the potential role for microglial activation
in diabetic retinal neuroinflammation is explored.
Investigators with authorship
University of Michigan-Ann Arbor
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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