Adiponectin effects on the kidney.
Authors Sweiss N, Sharma K
Submitted By Kumar Sharma on 3/12/2014
Status Published
Journal Best practice & research. Clinical endocrinology & metabolism
Year 2014
Date Published 1/1/2014
Volume : Pages 28 : 71 - 79
PubMed Reference 24417947
Abstract Adiponectin is a 30-kDa polypeptide secreted primarily by adipose tissue and
plays a key role in kidney disease. In obesity, reduced adiponectin levels are
associated with insulin resistance, cardiovascular disease and obesity related
kidney disease. The latter includes microalbuminuria, glomerulomegaly, overt
proteinuria and focal segmental glomerulosclerosis. Adiponectin levels in type 2
diabetics also negatively correlate with early features of nephropathy. However,
in patients with established chronic kidney disease, adiponectin levels are
elevated and positively predict progression of disease. The mechanism of action
of adiponectin in the kidney appears to be related to AMPK activation and NADPH
oxidase. Further studies are needed to elucidate this pathway and investigate
the role of potential targets of adiponectin-AMPK-Nox pathway for CKD as
obesity-related CKD is increasing worldwide.

Investigators with authorship
Kumar SharmaUniversity of California San Diego

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