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Publication

Adiponectin effects on the kidney.

Authors Sweiss N, Sharma K Submitted By Kumar Sharma on 3/12/2014 Status Published Journal Best practice & research. Clinical endocrinology & metabolism Year 2014 Date Published 1/1/2014 Volume : Pages 28 : 71 - 79 PubMed Reference 24417947 Abstract Adiponectin is a 30-kDa polypeptide secreted primarily by adipose tissue and plays a key role in kidney disease. In obesity, reduced adiponectin levels are associated with insulin resistance, cardiovascular disease and obesity related kidney disease. The latter includes microalbuminuria, glomerulomegaly, overt proteinuria and focal segmental glomerulosclerosis. Adiponectin levels in type 2 diabetics also negatively correlate with early features of nephropathy. However, in patients with established chronic kidney disease, adiponectin levels are elevated and positively predict progression of disease. The mechanism of action of adiponectin in the kidney appears to be related to AMPK activation and NADPH oxidase. Further studies are needed to elucidate this pathway and investigate the role of potential targets of adiponectin-AMPK-Nox pathway for CKD as obesity-related CKD is increasing worldwide.

Investigators with authorship
Name Institution Kumar Sharma University of California San Diego

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