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Glomerular cell death and inflammation with high-protein diet and diabetes.
Meek RL, LeBoeuf RC, Saha SA, Alpers CE, Hudkins KL, Cooney SK, Anderberg RJ,
Submitted Externally on 2/7/2014
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume : Pages
28 : 1711 - 1720
Overfeeding amino acids (AAs) increases cellular exposure to advanced glycation
end-products (AGEs), a mechanism for protein intake to worsen diabetic kidney
disease (DKD). This study assessed receptor for AGE (RAGE)-mediated apoptosis
and inflammation in glomerular cells exposed to metabolic stressors
characteristic of high-protein diets and/or diabetes in vitro with
proof-of-concept appraisal in vivo.
Investigators with authorship
University of Washington
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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