Glomerular cell death and inflammation with high-protein diet and diabetes.
Authors Meek RL, LeBoeuf RC, Saha SA, Alpers CE, Hudkins KL, Cooney SK, Anderberg RJ,
Tuttle KR
Submitted By Submitted Externally on 2/7/2014
Status Published
Journal Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Year 2013
Date Published 7/1/2013
Volume : Pages 28 : 1711 - 1720
PubMed Reference 23314315
Abstract Overfeeding amino acids (AAs) increases cellular exposure to advanced glycation
end-products (AGEs), a mechanism for protein intake to worsen diabetic kidney
disease (DKD). This study assessed receptor for AGE (RAGE)-mediated apoptosis
and inflammation in glomerular cells exposed to metabolic stressors
characteristic of high-protein diets and/or diabetes in vitro with
proof-of-concept appraisal in vivo.

Investigators with authorship
Charles AlpersUniversity of Washington