Autophagy and metabolic changes in obesity-related chronic kidney disease.
Authors Satriano J, Sharma K
Submitted By Kumar Sharma on 12/20/2013
Status Published
Journal Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Year 2013
Date Published 11/1/2013
Volume : Pages 28 Suppl 4 : iv29 - iv36
PubMed Reference 23901047
Abstract Obesity is a long-term source of cellular stress that predisposes to chronic
kidney disease (CKD). Autophagy is a homeostatic mechanism for cellular quality
control through the disposal and recycling of cellular components. During times
of cellular stress, autophagy affords mechanisms to manage stress by selectively
ridding the cell of the accumulation of potentially toxic proteins, lipids and
organelles. The adaptive processes employed may vary between cell types and
selectively adjust to the insult by inducing components of the basic autophagy
machinery utilized by the cells while not under duress. In this review, we will
discuss the autophagic responses of organs to cellular stressors, such as
high-fat diet, obesity and diabetes, and how these mechanisms may prevent or
promote the progression of disease. The identification of early cellular
mechanisms in the advent of obesity- and diabetes-related renal complications
could afford avenues for future therapeutic interventions.

Investigators with authorship
Kumar SharmaUniversity of California San Diego