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Publication

Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium.

Authors Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL Submitted By Submitted Externally on 10/29/2013 Status Published Journal Circulation research Year 2013 Date Published 8/2/2013 Volume : Pages 113 : 418 - 427 PubMed Reference 23759514 Abstract Loss of insulin action in the endothelium can cause endothelial dysfunction and atherosclerosis. Hyperglycemia and elevated fatty acids induced by diabetes mellitus can activate protein kinase C-ß isoforms and selectively inhibit insulin signaling via phosphatidylinositol 3-kinase/Akt pathway to inhibit the activation of endothelial nitric oxide synthase and metabolic actions.

Investigators with authorship
Name Institution Christian Rask-Madsen Joslin Diabetes Center - Boston

Complications
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