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Publication
Obesity, immunomodulation and chronic kidney disease.
Authors
Börgeson E, Sharma K
Submitted By
Kumar Sharma on 10/29/2013
Status
Published
Journal
Current opinion in pharmacology
Year
2013
Date Published
8/1/2013
Volume : Pages
13 : 618 - 624
PubMed Reference
23751262
Abstract
Obesity-induced inflammation is associated with numerous pathologies and is an
independent risk factor of chronic kidney disease (CKD). The prevalence of CKD
is escalating and current therapeutic strategies are seriously lacking in
efficacy, and immunomodulation has been suggested as a potential new therapeutic
approach. Indeed, specialized pro-resolving mediators (SPMs), such as lipoxins
(LXs), resolvins and protectins, have demonstrated protection in adipose
inflammation, restoring insulin sensitivity and adiponectin production, while
modulating leukocyte infiltration and promoting resolution in visceral adipose
tissue. Furthermore, SPMs display direct renoprotective effect. Thus we review
current evidence of immunomodulation as a potential strategy to subvert
obesity-related CKD.
Investigators with authorship
Name
Institution
Kumar Sharma
University of California San Diego
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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