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Publication

Vascular complications of diabetes: mechanisms of injury and protective factors.

Authors Rask-Madsen C, King GL Submitted By Submitted Externally on 7/10/2013 Status Published Journal Cell Metabolism Year 2013 Date Published 1/8/2013 Volume : Pages 17 : 20 - 33 PubMed Reference 23312281 Abstract In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy, and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal disease and blindness, respectively. An improved therapeutic approach to combat diabetic vascular complications might include blocking mechanisms of injury as well as promoting protective or regenerating factors, for example by enhancing the action of insulin-regulated genes in endothelial cells, promoting gene programs leading to induction of antioxidant or anti-inflammatory factors, or improving the sensitivity to vascular cell survival factors. Such strategies could help prevent complications despite suboptimal metabolic control.

Investigators with authorship
Name Institution Christian Rask-Madsen Joslin Diabetes Center - Boston

Complications
All Complications Bioinformatics Bone Cardiomyopathy Cardiovascular Gastro-Intestinal (GI) Nephropathy Neuropathy & Neurocognition Pediatric Endocrinology Retinopathy Uropathy Wound Healing