Mechanisms of lipotoxicity in the cardiovascular system.
Authors Wende AR, Symons JD, Abel ED
Submitted By E. Dale Abel on 7/10/2013
Status Published
Journal Current hypertension reports
Year 2012
Date Published 12/1/2012
Volume : Pages 14 : 517 - 531
PubMed Reference 23054891
Abstract Cardiovascular diseases account for approximately one third of all deaths
globally. Obese and diabetic patients have a high likelihood of dying from
complications associated with cardiovascular dysfunction. Obesity and diabetes
increase circulating lipids that upon tissue uptake, may be stored as
triglyceride, or may be metabolized in other pathways, leading to the generation
of toxic intermediates. Excess lipid utilization or activation of signaling
pathways by lipid metabolites may disrupt cellular homeostasis and contribute to
cell death, defining the concept of lipotoxicity. Lipotoxicity occurs in
multiple organs, including cardiac and vascular tissues, and a number of
specific mechanisms have been proposed to explain lipotoxic tissue injury. In
addition, recent data suggests that increased tissue lipids may also be
protective in certain contexts. This review will highlight recent progress
toward elucidating the relationship between nutrient oversupply, lipotoxicity,
and cardiovascular dysfunction. The review will focus in two sections on the
vasculature and cardiomyocytes respectively.

Investigators with authorship
E. Dale AbelUniversity of Iowa