Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure.
Authors Park TS, Goldberg IJ
Submitted By Ira Goldberg on 3/7/2013
Status Published
Journal Heart failure clinics
Year 2012
Date Published 10/1/2012
Volume : Pages 8 : 633 - 641
PubMed Reference 22999245
Abstract In the setting of obesity and type 2 diabetes mellitus, the ectopic disposition
of lipids may be a cause of heart failure. Clinical studies have clearly shown a
correlation between the accumulation of triglycerides and heart dysfunction. In
this process, it is likely that there are also changes in the contents of
sphingolipids. Sphingolipids are important structural and signaling molecules.
One specific sphingolipid, ceramide, may cause cardiac dysfunction, whereas
another, sphingosine 1-phosphate, is cardioprotective. In this review, the
authors focus on the role of sphingolipids in the development and prevention of
cardiac failure.

Investigators with authorship
Ira GoldbergNew York University School of Medicine