Role for GLUT1 in diabetic glomerulosclerosis.
Authors Heilig CW, Brosius FC, Cunningham C
Submitted By Frank Brosius on 2/23/2009
Status Published
Journal Expert reviews in molecular medicine
Year 2006
Date Published 3/7/2006
Volume : Pages 8(4) : 1
PubMed Reference 16515729
Abstract Numerous studies have investigated specific pathways that link diabetes and high
extracellular glucose exposure to glomerulosclerosis and mesangial cell
extracellular matrix production. However, only in the past ten years has a role
for glucose transporters in this process been addressed. Many different glucose
transporters are expressed in glomeruli; of these, the GLUT1 facilitative
glucose transporter is upregulated in the diabetic renal cortex and in response
to glomerular hypertension, as well as in cultured mesangial cells exposed to
high glucose. Transgenic mouse and cell models have recently been developed to
test the role of GLUT1 in the pathogenesis of glomerulosclerosis with and
without diabetes. Clinical studies of GLUT1 alleles performed in humans have
identified GLUT1 susceptibility alleles for diabetic nephropathy. Studies are
also currently under way to assess the potential role of GLUT1 in nondiabetic
renal disorders.

Investigators with authorship
Frank BrosiusUniversity of Arizona


Slc1a3solute carrier family 1, member 3
Slc2a1solute carrier family 2 (facilitated glucose transporter), member 1