Mouse models of diabetic neuropathy.
Authors Sullivan KA, Hayes JM, Wiggin TD, Backus C, Su Oh S, Lentz SI, Brosius F,
Feldman EL
Submitted By Eva Feldman on 2/23/2009
Status Published
Journal Neurobiology of disease
Year 2007
Date Published 12/1/2007
Volume : Pages 28(3) : 276 - 285
PubMed Reference 17804249
Abstract Diabetic neuropathy (DN) is a debilitating complication of type 1 and type 2
diabetes. Rodent models of DN do not fully replicate the pathology observed in
human patients. We examined DN in streptozotocin (STZ)-induced [B6] and
spontaneous type 1 diabetes [B6Ins2(Akita)] and spontaneous type 2 diabetes
[B6-db/db, BKS-db/db]. Despite persistent hyperglycemia, the STZ-treated B6 and
B6Ins2(Akita) mice were resistant to the development of DN. In contrast, DN
developed in both type 2 diabetes models: the B6-db/db and BKS-db/db mice. The
persistence of hyperglycemia and development of DN in the B6-db/db mice required
an increased fat diet while the BKS-db/db mice developed severe DN and remained
hyperglycemic on standard mouse chow. Our data support the hypothesis that
genetic background and diet influence the development of DN and should be
considered when developing new models of DN.

Investigators with authorship
Frank BrosiusUniversity of Arizona
Eva FeldmanUniversity of Michigan