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Mouse models of diabetic neuropathy.
Sullivan KA, Hayes JM, Wiggin TD, Backus C, Su Oh S, Lentz SI, Brosius F,
Eva Feldman on 2/23/2009
Neurobiology of disease
Volume : Pages
28(3) : 276 - 285
Diabetic neuropathy (DN) is a debilitating complication of type 1 and type 2
diabetes. Rodent models of DN do not fully replicate the pathology observed in
human patients. We examined DN in streptozotocin (STZ)-induced [B6] and
spontaneous type 1 diabetes [B6Ins2(Akita)] and spontaneous type 2 diabetes
[B6-db/db, BKS-db/db]. Despite persistent hyperglycemia, the STZ-treated B6 and
B6Ins2(Akita) mice were resistant to the development of DN. In contrast, DN
developed in both type 2 diabetes models: the B6-db/db and BKS-db/db mice. The
persistence of hyperglycemia and development of DN in the B6-db/db mice required
an increased fat diet while the BKS-db/db mice developed severe DN and remained
hyperglycemic on standard mouse chow. Our data support the hypothesis that
genetic background and diet influence the development of DN and should be
considered when developing new models of DN.
Investigators with authorship
University of Arizona
University of Michigan
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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