PPARgamma: a critical determinant of body fat distribution in humans and mice.
Authors Tsai YS, Maeda N
Submitted By Nobuyo Maeda on 2/23/2009
Status Published
Journal Trends in cardiovascular medicine
Year 2005
Date Published 4/1/2005
Volume : Pages 15(3) : 81 - 85
PubMed Reference 16039966
Abstract Evidence emerging from studies of humans and mice has indicated peroxisome
proliferator-activated receptor gamma (PPARgamma) to be not only a key factor
for adipogenesis but also a critical determinant of body fat distribution.
Whereas genetically reduced PPARgamma activity in adipose tissue leads to
reduction of total fat mass in humans and in mice, mutations in the
ligand-binding domain of PPARgamma cause abnormal body fat distributions. It is
less clear from mutation analysis how PPARgamma is involved in metabolic
disturbances such as insulin resistance and its cardiovascular complications.
Nevertheless, similarities and differences in the phenotypes associated with
PPARgamma mutations in humans and in mouse models provide opportunities to
dissect relationships between body fat distribution and its metabolic

Investigators with authorship
Nobuyo MaedaUniversity of North Carolina


Ppargperoxisome proliferator activated receptor gamma