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Publication

PPARgamma: a critical determinant of body fat distribution in humans and mice.

Authors Tsai YS, Maeda N Submitted By Nobuyo Maeda on 2/23/2009 Status Published Journal Trends in cardiovascular medicine Year 2005 Date Published 4/1/2005 Volume : Pages 15(3) : 81 - 85 PubMed Reference 16039966 Abstract Evidence emerging from studies of humans and mice has indicated peroxisome proliferator-activated receptor gamma (PPARgamma) to be not only a key factor for adipogenesis but also a critical determinant of body fat distribution. Whereas genetically reduced PPARgamma activity in adipose tissue leads to reduction of total fat mass in humans and in mice, mutations in the ligand-binding domain of PPARgamma cause abnormal body fat distributions. It is less clear from mutation analysis how PPARgamma is involved in metabolic disturbances such as insulin resistance and its cardiovascular complications. Nevertheless, similarities and differences in the phenotypes associated with PPARgamma mutations in humans and in mouse models provide opportunities to dissect relationships between body fat distribution and its metabolic complications.

Investigators with authorship
Name Institution Nobuyo Maeda University of North Carolina

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing

Genes
Symbol Description Pparg peroxisome proliferator activated receptor gamma