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alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes
in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet.
Yi X, Maeda N
Nobuyo Maeda on 2/23/2009
Volume : Pages
55(8) : 2238 - 2244
Considerable evidence indicates that hyperglycemia increases oxidative stress
and contributes to the increased incidence of atherosclerosis and cardiovascular
complications in diabetic patients. To examine the effect of alpha-lipoic acid,
a potent natural antioxidant, on atherosclerosis in diabetic mice, 3-month-old
apolipoprotein (apo) E-deficient (apoE(-/-)) mice were made diabetic by
administering streptozotocin (STZ). At 4 weeks after starting the STZ
administration, a high-fat diet with or without alpha-lipoic acid (1.65 g/kg)
was given to the mice and to nondiabetic apoE(-/-) controls. At 20 weeks,
markers of oxidative stress were significantly lower in both the diabetic
apoE(-/-) mice and their nondiabetic apoE(-/-) controls with alpha-lipoic acid
supplement than in those without it. Remarkably, alpha-lipoic acid completely
prevented the increase in plasma total cholesterol, atherosclerotic lesions, and
the general deterioration of health caused by diabetes. These protective effects
of alpha-lipoic acid were accompanied by a reduction of plasma glucose and an
accelerated recovery of insulin-producing cells in the pancreas, suggesting that
part of its effects are attributable to protecting pancreatic beta-cells from
damage. Our results suggest that dietary alpha-lipoic acid is a promising
protective agent for reducing cardiovascular complications of diabetes.
Investigators with authorship
University of North Carolina
Neuropathy & Neurocognition
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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