Insulin-like growth factors in the peripheral nervous system.
Authors Sullivan KA, Kim B, Feldman EL
Submitted By Eva Feldman on 2/8/2009
Status Published
Journal Endocrinology
Year 2008
Date Published 12/1/2008
Volume : Pages 149(12) : 5963 - 5971
PubMed Reference 18719018
Abstract IGF-I and -II are potent neuronal mitogens and survival factors. The actions of
IGF-I and -II are mediated via the type I IGF receptor (IGF-IR) and IGF binding
proteins regulate the bioavailability of the IGFs. Cell viability correlates
with IGF-IR expression and intact IGF-I/IGF-IR signaling pathways, including
activation of MAPK/phosphatidylinositol-3 kinase. The expression of IGF-I and
-II, IGF-IR, and IGF binding proteins are developmentally regulated in the
central and peripheral nervous system. IGF-I therapy demonstrates mixed
therapeutic results in the treatment of peripheral nerve injury, neuropathy, and
motor neuron diseases such as amyotrophic lateral sclerosis. In this review we
discuss the role of IGFs during peripheral nervous system development and the
IGF signaling system as the potential therapeutic target for the treatment of
nerve injury and motor neuron diseases.

Investigators with authorship
Eva FeldmanUniversity of Michigan


Igf1insulin-like growth factor 1